mneb/ade · Datasets at Hugging Face

input string	output dict	schema list
Eruptive epidermoid cysts resulting from treatment with imiquimod .	{ "relations": { "adverse effect": [ { "head": { "text": "Eruptive epidermoid cysts", "start": 0, "end": 25 }, "tail": { "text": "imiquimod", "start": 56, "end": 65 } } ] } }	[]
Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin .	{ "relations": { "adverse effect": [ { "head": { "text": "Bronchiolitis obliterans organising pneumonia", "start": 0, "end": 45 }, "tail": { "text": "nitrofurantoin", "start": 73, "end": 87 } } ] } }	[]
We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode .	{ "relations": { "adverse effect": [ { "head": { "text": "overanticoagulation", "start": 67, "end": 86 }, "tail": { "text": "acenocoumarol", "start": 102, "end": 115 } } ] } }	[]
Hypersensitivity to aspirin can be manifested as acute asthma , urticaria and/or angioedema , or a systemic anaphylactoid reaction .	{ "relations": { "adverse effect": [ { "head": { "text": "angioedema", "start": 81, "end": 91 }, "tail": { "text": "aspirin", "start": 20, "end": 27 } }, { "head": { "text": "systemic an...	[]
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin .	{ "relations": { "adverse effect": [ { "head": { "text": "severe hypersensitivity", "start": 152, "end": 175 }, "tail": { "text": "carboplatin", "start": 64, "end": 75 } } ] } }	[]
Although the data indicate an immune - complex cause for gold - salt nephropathy , the incident antigen ( or antigens ) and mechanism of action remain unidentified .	{ "relations": { "adverse effect": [ { "head": { "text": "nephropathy", "start": 69, "end": 80 }, "tail": { "text": "gold - salt", "start": 57, "end": 68 } } ] } }	[]
Phenylpropanolamine ( PPA ) recently has been publicly implicated as a cause of stroke and other neurologic events .	{ "relations": { "adverse effect": [ { "head": { "text": "neurologic events", "start": 97, "end": 114 }, "tail": { "text": "Phenylpropanolamine", "start": 0, "end": 19 } }, { "head": { "...	[]
Multiple complications of propylthiouracil treatment : granulocytopenia , eosinophilia , skin reaction and hepatitis with lymphocyte sensitization .	{ "relations": { "adverse effect": [ { "head": { "text": "eosinophilia", "start": 74, "end": 86 }, "tail": { "text": "propylthiouracil", "start": 26, "end": 42 } }, { "head": { "text": "...	[]
Hence , hyperthyroidism induced by IFN - alpha could correspond to the first phase of silent thyroiditis , to Graves ' disease or to the succession of both .	{ "relations": { "adverse effect": [ { "head": { "text": "hyperthyroidism", "start": 8, "end": 23 }, "tail": { "text": "IFN - alpha", "start": 35, "end": 46 } } ] } }	[]
This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue .	{ "relations": { "adverse effect": [ { "head": { "text": "hypersensitivity", "start": 63, "end": 79 }, "tail": { "text": "carboplatin", "start": 93, "end": 104 } } ] } }	[]
Thus , an immunological mechanism might be involved in the mechanism of pirmenol - induced QT prolongation and T wave inversion on the electrocardiogram .	{ "relations": { "adverse effect": [ { "head": { "text": "QT prolongation", "start": 91, "end": 106 }, "tail": { "text": "pirmenol", "start": 72, "end": 80 } }, { "head": { "text": "T wa...	[]
Magnesium tocolysis as the cause of urinary calculus during pregnancy .	{ "relations": { "adverse effect": [ { "head": { "text": "urinary calculus", "start": 36, "end": 52 }, "tail": { "text": "Magnesium", "start": 0, "end": 9 } } ] } }	[]
A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis .	{ "relations": { "adverse effect": [ { "head": { "text": "tuberculosis", "start": 10, "end": 22 }, "tail": { "text": "Efalizumab", "start": 39, "end": 49 } }, { "head": { "text": "tuberc...	[]
OBJECTIVES : The authors described a case of Hashimoto 's disease during interferon - alpha ( IFN - alpha ) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease .	{ "relations": { "adverse effect": [ { "head": { "text": "Hashimoto 's disease", "start": 45, "end": 65 }, "tail": { "text": "IFN - alpha", "start": 94, "end": 105 } }, { "head": { "text...	[]
Hepatic damage after danazol treatment .	{ "relations": { "adverse effect": [ { "head": { "text": "Hepatic damage", "start": 0, "end": 14 }, "tail": { "text": "danazol", "start": 21, "end": 28 } } ] } }	[]
Niacin maculopathy .	{ "relations": { "adverse effect": [ { "head": { "text": "maculopathy", "start": 7, "end": 18 }, "tail": { "text": "Niacin", "start": 0, "end": 6 } } ] } }	[]
Angioedema and dysphagia caused by contact allergy to inhaled budesonide .	{ "relations": { "adverse effect": [ { "head": { "text": "Angioedema", "start": 0, "end": 10 }, "tail": { "text": "budesonide", "start": 62, "end": 72 } }, { "head": { "text": "dysphagia...	[]
OBSERVATIONS : A 48-year - old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection .	{ "relations": { "adverse effect": [ { "head": { "text": "disfiguring facial edema", "start": 52, "end": 76 }, "tail": { "text": "peginterferon alfa-2a", "start": 125, "end": 146 } }, { "head": { ...	[]
A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement .	{ "relations": { "adverse effect": [ { "head": { "text": "pulmonary vasoconstriction", "start": 91, "end": 117 }, "tail": { "text": "protamine", "start": 174, "end": 183 } }, { "head": { ...	[]
Fatal pulmonary fibrosis associated with BCNU : the relative role of platelet - derived growth factor - B , insulin - like growth factor I , transforming growth factor - beta1 and cyclooxygenase-2 .	{ "relations": { "adverse effect": [ { "head": { "text": "Fatal pulmonary fibrosis", "start": 0, "end": 24 }, "tail": { "text": "BCNU", "start": 41, "end": 45 } } ] } }	[]
Syncope in a 65-year - old woman after nitrate ingestion .	{ "relations": { "adverse effect": [ { "head": { "text": "Syncope", "start": 0, "end": 7 }, "tail": { "text": "nitrate", "start": 39, "end": 46 } } ] } }	[]
A 57-year - old man developed morphea while taking bromocriptine .	{ "relations": { "adverse effect": [ { "head": { "text": "morphea", "start": 30, "end": 37 }, "tail": { "text": "bromocriptine", "start": 51, "end": 64 } } ] } }	[]
Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses .	{ "relations": { "adverse effect": [ { "head": { "text": "cardiac arrhythmias", "start": 71, "end": 90 }, "tail": { "text": "amphotericin B", "start": 113, "end": 127 } }, { "head": { "t...	[]
Clinicians who manage cachectic patients , particularly those with protracted diarrhoea and/or receiving anti - malarial drugs including mefloquine , should be aware of the risk of severe hypoglycaemia .	{ "relations": { "adverse effect": [ { "head": { "text": "severe hypoglycaemia", "start": 181, "end": 201 }, "tail": { "text": "mefloquine", "start": 137, "end": 147 } } ] } }	[]
MATERIALS AND METHODS : We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin .	{ "relations": { "adverse effect": [ { "head": { "text": "primary and secondary perforation of the bladder", "start": 81, "end": 129 }, "tail": { "text": "epirubicin", "start": 161, "end": 171 } } ] } }	[]
Gold nephropathy : tissue analysis by X - ray fluorescent spectroscopy .	{ "relations": { "adverse effect": [ { "head": { "text": "nephropathy", "start": 5, "end": 16 }, "tail": { "text": "Gold", "start": 0, "end": 4 } } ] } }	[]
Triazolam - induced nocturnal bingeing with amnesia .	{ "relations": { "adverse effect": [ { "head": { "text": "amnesia", "start": 44, "end": 51 }, "tail": { "text": "Triazolam", "start": 0, "end": 9 } }, { "head": { "text": "nocturnal bing...	[]
This case presentation is of a patient who had the clinical appearance of epiglottitis , but actually had an oro - pharyngeal dystonic reaction to prochlorperazine .	{ "relations": { "adverse effect": [ { "head": { "text": "epiglottitis", "start": 74, "end": 86 }, "tail": { "text": "prochlorperazine", "start": 147, "end": 163 } }, { "head": { "text":...	[]
The probable proarrhythmic action of amiodarone , although rare , is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy .	{ "relations": { "adverse effect": [ { "head": { "text": "proarrhythmic", "start": 13, "end": 26 }, "tail": { "text": "amiodarone", "start": 37, "end": 47 } } ] } }	[]
Five and one - half years after the diagnosis of myeloma , while in remission on cyclophosphamide therapy , the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma .	{ "relations": { "adverse effect": [ { "head": { "text": "abdominal right lower quadrant pain", "start": 139, "end": 174 }, "tail": { "text": "cyclophosphamide", "start": 81, "end": 97 } }, { "hea...	[]
OBJECTIVE : To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2 .	{ "relations": { "adverse effect": [ { "head": { "text": "cutaneous and hematologic toxicity", "start": 32, "end": 66 }, "tail": { "text": "IL-2", "start": 93, "end": 97 } } ] } }	[]
Sulfasalazine - induced lupus erythematosus .	{ "relations": { "adverse effect": [ { "head": { "text": "lupus erythematosus", "start": 24, "end": 43 }, "tail": { "text": "Sulfasalazine", "start": 0, "end": 13 } } ] } }	[]
Nephrotic syndrome associated with interferon - beta-1b therapy for multiple sclerosis .	{ "relations": { "adverse effect": [ { "head": { "text": "Nephrotic syndrome", "start": 0, "end": 18 }, "tail": { "text": "interferon - beta-1b", "start": 35, "end": 55 } } ] } }	[]
We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium ( Depakote ) , resulting in serum concentrations 10 times greater than the therapeutic range .	{ "relations": { "adverse effect": [ { "head": { "text": "symptomatic methemoglobinemia", "start": 48, "end": 77 }, "tail": { "text": "Depakote", "start": 126, "end": 134 } }, { "head": { ...	[]
CONCLUSIONS : In our reported case , a local hyperproduction of TNF - alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone .	{ "relations": { "adverse effect": [ { "head": { "text": "dedifferentiation of the adipocytes", "start": 152, "end": 187 }, "tail": { "text": "insulin", "start": 126, "end": 133 } }, { "head": { ...	[]
Renal injury due to anastrozole has not been published in the English literature .	{ "relations": { "adverse effect": [ { "head": { "text": "Renal injury", "start": 0, "end": 12 }, "tail": { "text": "anastrozole", "start": 20, "end": 31 } } ] } }	[]
Sustained - release procainamide - induced reversible granulocytopenia after myocardial infarction .	{ "relations": { "adverse effect": [ { "head": { "text": "reversible granulocytopenia", "start": 43, "end": 70 }, "tail": { "text": "procainamide", "start": 20, "end": 32 } } ] } }	[]
During clarithromycin coadministration , four out of the seven patients developed moderate - to - severe toxic symptoms of carbamazepine , such as drowsiness , dizziness , and ataxia , which resolved within 5 days after clarithromycin discontinuation .	{ "relations": { "adverse effect": [ { "head": { "text": "ataxia", "start": 176, "end": 182 }, "tail": { "text": "carbamazepine", "start": 123, "end": 136 } }, { "head": { "text": "ataxi...	[]
However , cyclosporine dependency is associated with the risk of nephrotoxicity .	{ "relations": { "adverse effect": [ { "head": { "text": "nephrotoxicity", "start": 65, "end": 79 }, "tail": { "text": "cyclosporine", "start": 10, "end": 22 } } ] } }	[]
We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication .	{ "relations": { "adverse effect": [ { "head": { "text": "acute hemorrhagic gastritis", "start": 75, "end": 102 }, "tail": { "text": "AZ", "start": 119, "end": 121 } }, { "head": { "text...	[]
We now report the first known cancer patient who developed life - threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency .	{ "relations": { "adverse effect": [ { "head": { "text": "life - threatening complications", "start": 59, "end": 91 }, "tail": { "text": "5-FU", "start": 121, "end": 125 } } ] } }	[]
To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy , we conducted a retrospective survey of 25 additional patients with Wilson 's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine .	{ "relations": { "adverse effect": [ { "head": { "text": "neurologic disease", "start": 255, "end": 273 }, "tail": { "text": "penicillamine", "start": 106, "end": 119 } }, { "head": { "t...	[]
Cephalosporins are most likely associated with Vitamin K deficiency .	{ "relations": { "adverse effect": [ { "head": { "text": "Vitamin K deficiency", "start": 47, "end": 67 }, "tail": { "text": "Cephalosporins", "start": 0, "end": 14 } } ] } }	[]
Multiple seizures after bupropion overdose in a small child .	{ "relations": { "adverse effect": [ { "head": { "text": "Multiple seizures", "start": 0, "end": 17 }, "tail": { "text": "bupropion", "start": 24, "end": 33 } } ] } }	[]
To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN - beta therapy for the malignant melanoma .	{ "relations": { "adverse effect": [ { "head": { "text": "histological abnormalities of the glomerulus", "start": 60, "end": 104 }, "tail": { "text": "IFN - beta", "start": 135, "end": 145 } } ] } }	[]
BACKGROUND : Reproductive endocrine disorders characterized by menstrual disorders , polycystic ovaries , and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy .	{ "relations": { "adverse effect": [ { "head": { "text": "hyperandrogenism", "start": 110, "end": 126 }, "tail": { "text": "sodium valproate", "start": 170, "end": 186 } }, { "head": { "...	[]
However , in order to avoid neuropathic side effects , patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug .	{ "relations": { "adverse effect": [ { "head": { "text": "neuropathic side effects", "start": 28, "end": 52 }, "tail": { "text": "thalidomide", "start": 70, "end": 81 } } ] } }	[]
Conventional and diffusion - weighted MRI findings of methotrexate related sub - acute neurotoxicity .	{ "relations": { "adverse effect": [ { "head": { "text": "sub - acute neurotoxicity", "start": 75, "end": 100 }, "tail": { "text": "methotrexate", "start": 54, "end": 66 } } ] } }	[]
The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus , therefore , in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment .	{ "relations": { "adverse effect": [ { "head": { "text": "type 1 diabetes mellitus", "start": 94, "end": 118 }, "tail": { "text": "recombinant alpha-2b peginterferon", "start": 35, "end": 69 } }, { ...	[]
A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non - haemorrhagic hypovolaemia is presented , with a discussion on the management and the use of allergy identification jewellery .	{ "relations": { "adverse effect": [ { "head": { "text": "anaphylactoid reaction", "start": 10, "end": 32 }, "tail": { "text": "Gelofusine", "start": 58, "end": 68 } } ] } }	[]
SUBSEQUENT COURSE : The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment .	{ "relations": { "adverse effect": [ { "head": { "text": "nephrosis", "start": 24, "end": 33 }, "tail": { "text": "interferon", "start": 70, "end": 80 } } ] } }	[]
The association of central diabetes insipidus ( CDI ) with lithium use is rare .	{ "relations": { "adverse effect": [ { "head": { "text": "CDI", "start": 48, "end": 51 }, "tail": { "text": "lithium", "start": 59, "end": 66 } }, { "head": { "text": "central diabetes i...	[]
Apparent central nervous system depression in infants after the use of topical brimonidine .	{ "relations": { "adverse effect": [ { "head": { "text": "central nervous system depression", "start": 9, "end": 42 }, "tail": { "text": "brimonidine", "start": 79, "end": 90 } } ] } }	[]
The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible , and that periodic urine testing in patients receiving pranlukast should be considered .	{ "relations": { "adverse effect": [ { "head": { "text": "ATIN", "start": 81, "end": 85 }, "tail": { "text": "pranlukast", "start": 56, "end": 66 } }, { "head": { "text": "ATIN", ...	[]
Five days after the fourth dose of vincristine , she presented with bilateral ptosis .	{ "relations": { "adverse effect": [ { "head": { "text": "bilateral ptosis", "start": 68, "end": 84 }, "tail": { "text": "vincristine", "start": 35, "end": 46 } } ] } }	[]
Clozapine induced polyserositis .	{ "relations": { "adverse effect": [ { "head": { "text": "polyserositis", "start": 18, "end": 31 }, "tail": { "text": "Clozapine", "start": 0, "end": 9 } } ] } }	[]
Four days after the initial injection of 3.6 mg of goserelin acetate , severe dyspnea developed due to worsening pleuritis carcinomatosa , which was considered as a flare - up .	{ "relations": { "adverse effect": [ { "head": { "text": "flare - up", "start": 165, "end": 175 }, "tail": { "text": "goserelin acetate", "start": 51, "end": 68 } }, { "head": { "text": ...	[]
Second , we report a case of neutropenia , which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide .	{ "relations": { "adverse effect": [ { "head": { "text": "neutropenia", "start": 29, "end": 40 }, "tail": { "text": "olanzapine", "start": 105, "end": 115 } }, { "head": { "text": "neutr...	[]
In two patients with mycosis fungoides , a squamous cell carcinoma developed during therapy with psoralens plus long - wave ultraviolet radiation ( PUVA ) .	{ "relations": { "adverse effect": [ { "head": { "text": "squamous cell carcinoma", "start": 43, "end": 66 }, "tail": { "text": "psoralens", "start": 97, "end": 106 } } ] } }	[]
Flurbiprofen - associated acute tubulointerstitial nephritis .	{ "relations": { "adverse effect": [ { "head": { "text": "acute tubulointerstitial nephritis", "start": 26, "end": 60 }, "tail": { "text": "Flurbiprofen", "start": 0, "end": 12 } } ] } }	[]
The mechanism of anaphylactoid reaction to zomepirac in this case , therefore , remains unclear .	{ "relations": { "adverse effect": [ { "head": { "text": "anaphylactoid reaction", "start": 17, "end": 39 }, "tail": { "text": "zomepirac", "start": 43, "end": 52 } } ] } }	[]
L - asparaginase - provoked seizures as singular expression of central nervous toxicity .	{ "relations": { "adverse effect": [ { "head": { "text": "central nervous toxicity", "start": 63, "end": 87 }, "tail": { "text": "L - asparaginase", "start": 0, "end": 16 } }, { "head": { ...	[]
Possible linkage of amprenavir with intracranial bleeding in an HIV - infected hemophiliac .	{ "relations": { "adverse effect": [ { "head": { "text": "intracranial bleeding", "start": 36, "end": 57 }, "tail": { "text": "amprenavir", "start": 20, "end": 30 } } ] } }	[]
Within 24 hours of fluid restriction and cessation of desmopressin , her symptoms and hyponatremia resolved .	{ "relations": { "adverse effect": [ { "head": { "text": "hyponatremia", "start": 86, "end": 98 }, "tail": { "text": "desmopressin", "start": 54, "end": 66 } } ] } }	[]
A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma .	{ "relations": { "adverse effect": [ { "head": { "text": "ulcer", "start": 128, "end": 133 }, "tail": { "text": "theophylline", "start": 42, "end": 54 } }, { "head": { "text": "ulcer", ...	[]
High - dose intravenous mannitol infusion in various clinical settings may result in acute renal failure ( ARF ) .	{ "relations": { "adverse effect": [ { "head": { "text": "acute renal failure", "start": 85, "end": 104 }, "tail": { "text": "mannitol", "start": 24, "end": 32 } }, { "head": { "text": "...	[]
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving ' standard ' doses of dexamethasone as part of the antiemetic regimen used in cisplatin - based combination chemotherapy .	{ "relations": { "adverse effect": [ { "head": { "text": "bilateral avascular necrosis of the femoral heads", "start": 30, "end": 79 }, "tail": { "text": "dexamethasone", "start": 125, "end": 138 } } ] } ...	[]
CASE SUMMARY : A 46-year - old African - American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B , then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time .	{ "relations": { "adverse effect": [ { "head": { "text": "grand mal seizures", "start": 76, "end": 94 }, "tail": { "text": "amphotericin B", "start": 126, "end": 140 } } ] } }	[]
Because psoralens sensitize skin to ultraviolet A light , phototoxic reactions are the most frequent adverse effect of this treatment .	{ "relations": { "adverse effect": [ { "head": { "text": "phototoxic reactions", "start": 58, "end": 78 }, "tail": { "text": "psoralens", "start": 8, "end": 17 } } ] } }	[]
We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy .	{ "relations": { "adverse effect": [ { "head": { "text": "supravenous hyperpigmentation", "start": 32, "end": 61 }, "tail": { "text": "CHOP", "start": 78, "end": 82 } } ] } }	[]
The authors present a case study of a mentally healthy man who repeatedly experienced short - lived , obsessional - like suicidal ideas and images after ingestion of the anti - fungal drug ketoconazole .	{ "relations": { "adverse effect": [ { "head": { "text": "obsessional - like suicidal ideas and images", "start": 102, "end": 146 }, "tail": { "text": "ketoconazole", "start": 189, "end": 201 } } ] } }	[]
After extensive neurological ' work up ' , we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid .	{ "relations": { "adverse effect": [ { "head": { "text": "anisocoria", "start": 64, "end": 74 }, "tail": { "text": "scopolamine", "start": 106, "end": 117 } } ] } }	[]
We assume that rIFN - gamma induced the de novo development of SLE in our patient .	{ "relations": { "adverse effect": [ { "head": { "text": "SLE", "start": 63, "end": 66 }, "tail": { "text": "rIFN - gamma", "start": 15, "end": 27 } } ] } }	[]
Atrial fibrillation following methylprednisolone pulse therapy .	{ "relations": { "adverse effect": [ { "head": { "text": "Atrial fibrillation", "start": 0, "end": 19 }, "tail": { "text": "methylprednisolone", "start": 30, "end": 48 } } ] } }	[]
One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin .	{ "relations": { "adverse effect": [ { "head": { "text": "erythema multiforme", "start": 56, "end": 75 }, "tail": { "text": "griseofulvin", "start": 89, "end": 101 } } ] } }	[]
She was receiving phenytoin sodium 300 mg / day ; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia .	{ "relations": { "adverse effect": [ { "head": { "text": "leukopenia", "start": 148, "end": 158 }, "tail": { "text": "carbamazepine", "start": 50, "end": 63 } }, { "head": { "text": "leu...	[]
We describe the case of acute hepatitis induced by gliclazide , a second generation sulfonylurea .	{ "relations": { "adverse effect": [ { "head": { "text": "acute hepatitis", "start": 24, "end": 39 }, "tail": { "text": "gliclazide", "start": 51, "end": 61 } } ] } }	[]
OBJECTIVE : To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine .	{ "relations": { "adverse effect": [ { "head": { "text": "allergic reactions", "start": 91, "end": 109 }, "tail": { "text": "capecitabine", "start": 113, "end": 125 } } ] } }	[]
A patient with chronic myeloid leukaemia treated with busulphan for 4 - 5 years , developed signs of busulphan toxicity and portal hypertension with ascites , oesophageal varices and jaundice .	{ "relations": { "adverse effect": [ { "head": { "text": "ascites", "start": 149, "end": 156 }, "tail": { "text": "busulphan", "start": 54, "end": 63 } }, { "head": { "text": "jaundice",...	[]
Niflumic acid - induced skeletal fluorosis : iatrogenic disease or therapeutic perspective for osteoporosis ?	{ "relations": { "adverse effect": [ { "head": { "text": "skeletal fluorosis", "start": 24, "end": 42 }, "tail": { "text": "Niflumic acid", "start": 0, "end": 13 } } ] } }	[]
Hyponatraemia developed after rechallenge with controlled release carbamazepine .	{ "relations": { "adverse effect": [ { "head": { "text": "Hyponatraemia", "start": 0, "end": 13 }, "tail": { "text": "carbamazepine", "start": 66, "end": 79 } } ] } }	[]
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea .	{ "relations": { "adverse effect": [ { "head": { "text": "CML", "start": 71, "end": 74 }, "tail": { "text": "hydroxyurea", "start": 97, "end": 108 } } ] } }	[]
The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril - induced acute renal failure .	{ "relations": { "adverse effect": [ { "head": { "text": "acute renal failure", "start": 142, "end": 161 }, "tail": { "text": "captopril", "start": 122, "end": 131 } } ] } }	[]
Since 1979 , over 30 published case reports have documented the relationship between phenylpropanolamine and stroke .	{ "relations": { "adverse effect": [ { "head": { "text": "stroke", "start": 109, "end": 115 }, "tail": { "text": "phenylpropanolamine", "start": 85, "end": 104 } } ] } }	[]
DISCUSSION : To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept .	{ "relations": { "adverse effect": [ { "head": { "text": "tuberculous uveitis", "start": 65, "end": 84 }, "tail": { "text": "etanercept", "start": 110, "end": 120 } } ] } }	[]
We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome , a rare congenital disorder .	{ "relations": { "adverse effect": [ { "head": { "text": "interstitial hypoxaemiant pneumonitis", "start": 22, "end": 59 }, "tail": { "text": "flecainide", "start": 80, "end": 90 } } ] } }	[]
Methotrexate - induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis : report of five cases and review of the literature .	{ "relations": { "adverse effect": [ { "head": { "text": "pneumonitis", "start": 23, "end": 34 }, "tail": { "text": "Methotrexate", "start": 0, "end": 12 } } ] } }	[]
While 40 mg / day of prednisolone improved hepatic dysfunction dramatically , her diabetic milieu deteriorated seriously .	{ "relations": { "adverse effect": [ { "head": { "text": "diabetic milieu deteriorated", "start": 82, "end": 110 }, "tail": { "text": "prednisolone", "start": 21, "end": 33 } } ] } }	[]
Ulcerating enteritis associated with flucytosine therapy .	{ "relations": { "adverse effect": [ { "head": { "text": "Ulcerating enteritis", "start": 0, "end": 20 }, "tail": { "text": "flucytosine", "start": 37, "end": 48 } } ] } }	[]
CONCLUSION : This rare case of PTU - induced ANCA - associated vasculitis manifested with ototoxicity in combination with systemic involvement .	{ "relations": { "adverse effect": [ { "head": { "text": "ANCA - associated vasculitis", "start": 45, "end": 73 }, "tail": { "text": "PTU", "start": 31, "end": 34 } }, { "head": { "text"...	[]
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding .	{ "relations": { "adverse effect": [ { "head": { "text": "HUS", "start": 36, "end": 39 }, "tail": { "text": "MMC", "start": 46, "end": 49 } }, { "head": { "text": "massive pulmonary blee...	[]
CONCLUSION : These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers .	{ "relations": { "adverse effect": [ { "head": { "text": "corneal ulcers", "start": 85, "end": 99 }, "tail": { "text": "moxifloxacin", "start": 38, "end": 50 } } ] } }	[]
CONCLUSION : During and after IFN therapy , OCT is a useful examination technique for revealing macular edema in patients who have decreased vision .	{ "relations": { "adverse effect": [ { "head": { "text": "decreased vision", "start": 131, "end": 147 }, "tail": { "text": "IFN", "start": 30, "end": 33 } }, { "head": { "text": "macular...	[]
Although the two local anesthetics usually do not cause methemoglobinemia , we suspect that the displacement of lidocaine from protein binding by bupivacaine , in combination with metabolic acidosis and treatment with other oxidants , was the reason for the development of methemoglobinemia .	{ "relations": { "adverse effect": [ { "head": { "text": "methemoglobinemia", "start": 56, "end": 73 }, "tail": { "text": "lidocaine", "start": 112, "end": 121 } } ] } }	[]
Here we describe another case of VOD occurring after LT , but in which the causative role was played by azathioprine .	{ "relations": { "adverse effect": [ { "head": { "text": "VOD", "start": 33, "end": 36 }, "tail": { "text": "azathioprine", "start": 104, "end": 116 } } ] } }	[]
Hypo - oestrogenic and anabolic / androgenic side - effects of danazol are well known by the gynaecologist and some of them are present in > 50 % of patients being treated for endometriosis .	{ "relations": { "adverse effect": [ { "head": { "text": "Hypo - oestrogenic and anabolic / androgenic side - effects", "start": 0, "end": 59 }, "tail": { "text": "danazol", "start": 63, "end": 70 } } ] }...	[]
The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine .	{ "relations": { "adverse effect": [ { "head": { "text": "transient intraoperative hypertension", "start": 28, "end": 65 }, "tail": { "text": "epinephrine", "start": 133, "end": 144 } } ] } }	[]
Inadvertent and accidental epinephrine overdose might result in potentially lethal complications .	{ "relations": { "adverse effect": [ { "head": { "text": "lethal complications", "start": 76, "end": 96 }, "tail": { "text": "epinephrine", "start": 27, "end": 38 } } ] } }	[]
Acute pancreatitis is a known , although rare , complication of mesalamine treatment .	{ "relations": { "adverse effect": [ { "head": { "text": "Acute pancreatitis", "start": 0, "end": 18 }, "tail": { "text": "mesalamine", "start": 64, "end": 74 } } ] } }	[]
From these data , acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d - penicillamine therapy .	{ "relations": { "adverse effect": [ { "head": { "text": "acute generalized dystonia", "start": 18, "end": 44 }, "tail": { "text": "d - penicillamine", "start": 123, "end": 140 } }, { "head": { ...	[]

Eruptive epidermoid cysts resulting from treatment with imiquimod .

{ "relations": { "adverse effect": [ { "head": { "text": "Eruptive epidermoid cysts", "start": 0, "end": 25 }, "tail": { "text": "imiquimod", "start": 56, "end": 65 } } ] } }

[]

Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin .

{ "relations": { "adverse effect": [ { "head": { "text": "Bronchiolitis obliterans organising pneumonia", "start": 0, "end": 45 }, "tail": { "text": "nitrofurantoin", "start": 73, "end": 87 } } ] } }

[]

We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode .

{ "relations": { "adverse effect": [ { "head": { "text": "overanticoagulation", "start": 67, "end": 86 }, "tail": { "text": "acenocoumarol", "start": 102, "end": 115 } } ] } }

[]

Hypersensitivity to aspirin can be manifested as acute asthma , urticaria and/or angioedema , or a systemic anaphylactoid reaction .

{ "relations": { "adverse effect": [ { "head": { "text": "angioedema", "start": 81, "end": 91 }, "tail": { "text": "aspirin", "start": 20, "end": 27 } }, { "head": { "text": "systemic an...

[]

Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin .

{ "relations": { "adverse effect": [ { "head": { "text": "severe hypersensitivity", "start": 152, "end": 175 }, "tail": { "text": "carboplatin", "start": 64, "end": 75 } } ] } }

[]

Although the data indicate an immune - complex cause for gold - salt nephropathy , the incident antigen ( or antigens ) and mechanism of action remain unidentified .

{ "relations": { "adverse effect": [ { "head": { "text": "nephropathy", "start": 69, "end": 80 }, "tail": { "text": "gold - salt", "start": 57, "end": 68 } } ] } }

[]

Phenylpropanolamine ( PPA ) recently has been publicly implicated as a cause of stroke and other neurologic events .

{ "relations": { "adverse effect": [ { "head": { "text": "neurologic events", "start": 97, "end": 114 }, "tail": { "text": "Phenylpropanolamine", "start": 0, "end": 19 } }, { "head": { "...

[]

Multiple complications of propylthiouracil treatment : granulocytopenia , eosinophilia , skin reaction and hepatitis with lymphocyte sensitization .

{ "relations": { "adverse effect": [ { "head": { "text": "eosinophilia", "start": 74, "end": 86 }, "tail": { "text": "propylthiouracil", "start": 26, "end": 42 } }, { "head": { "text": "...

[]

Hence , hyperthyroidism induced by IFN - alpha could correspond to the first phase of silent thyroiditis , to Graves ' disease or to the succession of both .

{ "relations": { "adverse effect": [ { "head": { "text": "hyperthyroidism", "start": 8, "end": 23 }, "tail": { "text": "IFN - alpha", "start": 35, "end": 46 } } ] } }

[]

This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue .

{ "relations": { "adverse effect": [ { "head": { "text": "hypersensitivity", "start": 63, "end": 79 }, "tail": { "text": "carboplatin", "start": 93, "end": 104 } } ] } }

[]

Thus , an immunological mechanism might be involved in the mechanism of pirmenol - induced QT prolongation and T wave inversion on the electrocardiogram .

{ "relations": { "adverse effect": [ { "head": { "text": "QT prolongation", "start": 91, "end": 106 }, "tail": { "text": "pirmenol", "start": 72, "end": 80 } }, { "head": { "text": "T wa...

[]

Magnesium tocolysis as the cause of urinary calculus during pregnancy .

{ "relations": { "adverse effect": [ { "head": { "text": "urinary calculus", "start": 36, "end": 52 }, "tail": { "text": "Magnesium", "start": 0, "end": 9 } } ] } }

[]

A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis .

{ "relations": { "adverse effect": [ { "head": { "text": "tuberculosis", "start": 10, "end": 22 }, "tail": { "text": "Efalizumab", "start": 39, "end": 49 } }, { "head": { "text": "tuberc...

[]

OBJECTIVES : The authors described a case of Hashimoto 's disease during interferon - alpha ( IFN - alpha ) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease .

{ "relations": { "adverse effect": [ { "head": { "text": "Hashimoto 's disease", "start": 45, "end": 65 }, "tail": { "text": "IFN - alpha", "start": 94, "end": 105 } }, { "head": { "text...

[]

Hepatic damage after danazol treatment .

{ "relations": { "adverse effect": [ { "head": { "text": "Hepatic damage", "start": 0, "end": 14 }, "tail": { "text": "danazol", "start": 21, "end": 28 } } ] } }

[]

Niacin maculopathy .

{ "relations": { "adverse effect": [ { "head": { "text": "maculopathy", "start": 7, "end": 18 }, "tail": { "text": "Niacin", "start": 0, "end": 6 } } ] } }

[]

Angioedema and dysphagia caused by contact allergy to inhaled budesonide .

{ "relations": { "adverse effect": [ { "head": { "text": "Angioedema", "start": 0, "end": 10 }, "tail": { "text": "budesonide", "start": 62, "end": 72 } }, { "head": { "text": "dysphagia...

[]

OBSERVATIONS : A 48-year - old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection .

{ "relations": { "adverse effect": [ { "head": { "text": "disfiguring facial edema", "start": 52, "end": 76 }, "tail": { "text": "peginterferon alfa-2a", "start": 125, "end": 146 } }, { "head": { ...

[]

A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement .

{ "relations": { "adverse effect": [ { "head": { "text": "pulmonary vasoconstriction", "start": 91, "end": 117 }, "tail": { "text": "protamine", "start": 174, "end": 183 } }, { "head": { ...

[]

Fatal pulmonary fibrosis associated with BCNU : the relative role of platelet - derived growth factor - B , insulin - like growth factor I , transforming growth factor - beta1 and cyclooxygenase-2 .

{ "relations": { "adverse effect": [ { "head": { "text": "Fatal pulmonary fibrosis", "start": 0, "end": 24 }, "tail": { "text": "BCNU", "start": 41, "end": 45 } } ] } }

[]

Syncope in a 65-year - old woman after nitrate ingestion .

{ "relations": { "adverse effect": [ { "head": { "text": "Syncope", "start": 0, "end": 7 }, "tail": { "text": "nitrate", "start": 39, "end": 46 } } ] } }

[]

A 57-year - old man developed morphea while taking bromocriptine .

{ "relations": { "adverse effect": [ { "head": { "text": "morphea", "start": 30, "end": 37 }, "tail": { "text": "bromocriptine", "start": 51, "end": 64 } } ] } }

[]

Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses .

{ "relations": { "adverse effect": [ { "head": { "text": "cardiac arrhythmias", "start": 71, "end": 90 }, "tail": { "text": "amphotericin B", "start": 113, "end": 127 } }, { "head": { "t...

[]

Clinicians who manage cachectic patients , particularly those with protracted diarrhoea and/or receiving anti - malarial drugs including mefloquine , should be aware of the risk of severe hypoglycaemia .

{ "relations": { "adverse effect": [ { "head": { "text": "severe hypoglycaemia", "start": 181, "end": 201 }, "tail": { "text": "mefloquine", "start": 137, "end": 147 } } ] } }

[]

MATERIALS AND METHODS : We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin .

{ "relations": { "adverse effect": [ { "head": { "text": "primary and secondary perforation of the bladder", "start": 81, "end": 129 }, "tail": { "text": "epirubicin", "start": 161, "end": 171 } } ] } }

[]

Gold nephropathy : tissue analysis by X - ray fluorescent spectroscopy .

{ "relations": { "adverse effect": [ { "head": { "text": "nephropathy", "start": 5, "end": 16 }, "tail": { "text": "Gold", "start": 0, "end": 4 } } ] } }

[]

Triazolam - induced nocturnal bingeing with amnesia .

{ "relations": { "adverse effect": [ { "head": { "text": "amnesia", "start": 44, "end": 51 }, "tail": { "text": "Triazolam", "start": 0, "end": 9 } }, { "head": { "text": "nocturnal bing...

[]

This case presentation is of a patient who had the clinical appearance of epiglottitis , but actually had an oro - pharyngeal dystonic reaction to prochlorperazine .

{ "relations": { "adverse effect": [ { "head": { "text": "epiglottitis", "start": 74, "end": 86 }, "tail": { "text": "prochlorperazine", "start": 147, "end": 163 } }, { "head": { "text":...

[]

The probable proarrhythmic action of amiodarone , although rare , is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy .

{ "relations": { "adverse effect": [ { "head": { "text": "proarrhythmic", "start": 13, "end": 26 }, "tail": { "text": "amiodarone", "start": 37, "end": 47 } } ] } }

[]

Five and one - half years after the diagnosis of myeloma , while in remission on cyclophosphamide therapy , the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma .

{ "relations": { "adverse effect": [ { "head": { "text": "abdominal right lower quadrant pain", "start": 139, "end": 174 }, "tail": { "text": "cyclophosphamide", "start": 81, "end": 97 } }, { "hea...

[]

OBJECTIVE : To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2 .

{ "relations": { "adverse effect": [ { "head": { "text": "cutaneous and hematologic toxicity", "start": 32, "end": 66 }, "tail": { "text": "IL-2", "start": 93, "end": 97 } } ] } }

[]

Sulfasalazine - induced lupus erythematosus .

{ "relations": { "adverse effect": [ { "head": { "text": "lupus erythematosus", "start": 24, "end": 43 }, "tail": { "text": "Sulfasalazine", "start": 0, "end": 13 } } ] } }

[]

Nephrotic syndrome associated with interferon - beta-1b therapy for multiple sclerosis .

{ "relations": { "adverse effect": [ { "head": { "text": "Nephrotic syndrome", "start": 0, "end": 18 }, "tail": { "text": "interferon - beta-1b", "start": 35, "end": 55 } } ] } }

[]

We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium ( Depakote ) , resulting in serum concentrations 10 times greater than the therapeutic range .

{ "relations": { "adverse effect": [ { "head": { "text": "symptomatic methemoglobinemia", "start": 48, "end": 77 }, "tail": { "text": "Depakote", "start": 126, "end": 134 } }, { "head": { ...

[]

CONCLUSIONS : In our reported case , a local hyperproduction of TNF - alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone .

{ "relations": { "adverse effect": [ { "head": { "text": "dedifferentiation of the adipocytes", "start": 152, "end": 187 }, "tail": { "text": "insulin", "start": 126, "end": 133 } }, { "head": { ...

[]

Renal injury due to anastrozole has not been published in the English literature .

{ "relations": { "adverse effect": [ { "head": { "text": "Renal injury", "start": 0, "end": 12 }, "tail": { "text": "anastrozole", "start": 20, "end": 31 } } ] } }

[]

Sustained - release procainamide - induced reversible granulocytopenia after myocardial infarction .

{ "relations": { "adverse effect": [ { "head": { "text": "reversible granulocytopenia", "start": 43, "end": 70 }, "tail": { "text": "procainamide", "start": 20, "end": 32 } } ] } }

[]

During clarithromycin coadministration , four out of the seven patients developed moderate - to - severe toxic symptoms of carbamazepine , such as drowsiness , dizziness , and ataxia , which resolved within 5 days after clarithromycin discontinuation .

{ "relations": { "adverse effect": [ { "head": { "text": "ataxia", "start": 176, "end": 182 }, "tail": { "text": "carbamazepine", "start": 123, "end": 136 } }, { "head": { "text": "ataxi...

[]

However , cyclosporine dependency is associated with the risk of nephrotoxicity .

{ "relations": { "adverse effect": [ { "head": { "text": "nephrotoxicity", "start": 65, "end": 79 }, "tail": { "text": "cyclosporine", "start": 10, "end": 22 } } ] } }

[]

We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication .

{ "relations": { "adverse effect": [ { "head": { "text": "acute hemorrhagic gastritis", "start": 75, "end": 102 }, "tail": { "text": "AZ", "start": 119, "end": 121 } }, { "head": { "text...

[]

We now report the first known cancer patient who developed life - threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency .

{ "relations": { "adverse effect": [ { "head": { "text": "life - threatening complications", "start": 59, "end": 91 }, "tail": { "text": "5-FU", "start": 121, "end": 125 } } ] } }

[]

To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy , we conducted a retrospective survey of 25 additional patients with Wilson 's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine .

{ "relations": { "adverse effect": [ { "head": { "text": "neurologic disease", "start": 255, "end": 273 }, "tail": { "text": "penicillamine", "start": 106, "end": 119 } }, { "head": { "t...

[]

Cephalosporins are most likely associated with Vitamin K deficiency .

{ "relations": { "adverse effect": [ { "head": { "text": "Vitamin K deficiency", "start": 47, "end": 67 }, "tail": { "text": "Cephalosporins", "start": 0, "end": 14 } } ] } }

[]

Multiple seizures after bupropion overdose in a small child .

{ "relations": { "adverse effect": [ { "head": { "text": "Multiple seizures", "start": 0, "end": 17 }, "tail": { "text": "bupropion", "start": 24, "end": 33 } } ] } }

[]

To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN - beta therapy for the malignant melanoma .

{ "relations": { "adverse effect": [ { "head": { "text": "histological abnormalities of the glomerulus", "start": 60, "end": 104 }, "tail": { "text": "IFN - beta", "start": 135, "end": 145 } } ] } }

[]

BACKGROUND : Reproductive endocrine disorders characterized by menstrual disorders , polycystic ovaries , and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy .

{ "relations": { "adverse effect": [ { "head": { "text": "hyperandrogenism", "start": 110, "end": 126 }, "tail": { "text": "sodium valproate", "start": 170, "end": 186 } }, { "head": { "...

[]

However , in order to avoid neuropathic side effects , patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug .

{ "relations": { "adverse effect": [ { "head": { "text": "neuropathic side effects", "start": 28, "end": 52 }, "tail": { "text": "thalidomide", "start": 70, "end": 81 } } ] } }

[]

Conventional and diffusion - weighted MRI findings of methotrexate related sub - acute neurotoxicity .

{ "relations": { "adverse effect": [ { "head": { "text": "sub - acute neurotoxicity", "start": 75, "end": 100 }, "tail": { "text": "methotrexate", "start": 54, "end": 66 } } ] } }

[]

The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus , therefore , in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment .

{ "relations": { "adverse effect": [ { "head": { "text": "type 1 diabetes mellitus", "start": 94, "end": 118 }, "tail": { "text": "recombinant alpha-2b peginterferon", "start": 35, "end": 69 } }, { ...

[]

A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non - haemorrhagic hypovolaemia is presented , with a discussion on the management and the use of allergy identification jewellery .

{ "relations": { "adverse effect": [ { "head": { "text": "anaphylactoid reaction", "start": 10, "end": 32 }, "tail": { "text": "Gelofusine", "start": 58, "end": 68 } } ] } }

[]

SUBSEQUENT COURSE : The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment .

{ "relations": { "adverse effect": [ { "head": { "text": "nephrosis", "start": 24, "end": 33 }, "tail": { "text": "interferon", "start": 70, "end": 80 } } ] } }

[]

The association of central diabetes insipidus ( CDI ) with lithium use is rare .

{ "relations": { "adverse effect": [ { "head": { "text": "CDI", "start": 48, "end": 51 }, "tail": { "text": "lithium", "start": 59, "end": 66 } }, { "head": { "text": "central diabetes i...

[]

Apparent central nervous system depression in infants after the use of topical brimonidine .

{ "relations": { "adverse effect": [ { "head": { "text": "central nervous system depression", "start": 9, "end": 42 }, "tail": { "text": "brimonidine", "start": 79, "end": 90 } } ] } }

[]

The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible , and that periodic urine testing in patients receiving pranlukast should be considered .

{ "relations": { "adverse effect": [ { "head": { "text": "ATIN", "start": 81, "end": 85 }, "tail": { "text": "pranlukast", "start": 56, "end": 66 } }, { "head": { "text": "ATIN", ...

[]

Five days after the fourth dose of vincristine , she presented with bilateral ptosis .

{ "relations": { "adverse effect": [ { "head": { "text": "bilateral ptosis", "start": 68, "end": 84 }, "tail": { "text": "vincristine", "start": 35, "end": 46 } } ] } }

[]

Clozapine induced polyserositis .

{ "relations": { "adverse effect": [ { "head": { "text": "polyserositis", "start": 18, "end": 31 }, "tail": { "text": "Clozapine", "start": 0, "end": 9 } } ] } }

[]

Four days after the initial injection of 3.6 mg of goserelin acetate , severe dyspnea developed due to worsening pleuritis carcinomatosa , which was considered as a flare - up .

{ "relations": { "adverse effect": [ { "head": { "text": "flare - up", "start": 165, "end": 175 }, "tail": { "text": "goserelin acetate", "start": 51, "end": 68 } }, { "head": { "text": ...

[]

Second , we report a case of neutropenia , which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide .

{ "relations": { "adverse effect": [ { "head": { "text": "neutropenia", "start": 29, "end": 40 }, "tail": { "text": "olanzapine", "start": 105, "end": 115 } }, { "head": { "text": "neutr...

[]

In two patients with mycosis fungoides , a squamous cell carcinoma developed during therapy with psoralens plus long - wave ultraviolet radiation ( PUVA ) .

{ "relations": { "adverse effect": [ { "head": { "text": "squamous cell carcinoma", "start": 43, "end": 66 }, "tail": { "text": "psoralens", "start": 97, "end": 106 } } ] } }

[]

Flurbiprofen - associated acute tubulointerstitial nephritis .

{ "relations": { "adverse effect": [ { "head": { "text": "acute tubulointerstitial nephritis", "start": 26, "end": 60 }, "tail": { "text": "Flurbiprofen", "start": 0, "end": 12 } } ] } }

[]

The mechanism of anaphylactoid reaction to zomepirac in this case , therefore , remains unclear .

{ "relations": { "adverse effect": [ { "head": { "text": "anaphylactoid reaction", "start": 17, "end": 39 }, "tail": { "text": "zomepirac", "start": 43, "end": 52 } } ] } }

[]

L - asparaginase - provoked seizures as singular expression of central nervous toxicity .

{ "relations": { "adverse effect": [ { "head": { "text": "central nervous toxicity", "start": 63, "end": 87 }, "tail": { "text": "L - asparaginase", "start": 0, "end": 16 } }, { "head": { ...

[]

Possible linkage of amprenavir with intracranial bleeding in an HIV - infected hemophiliac .

{ "relations": { "adverse effect": [ { "head": { "text": "intracranial bleeding", "start": 36, "end": 57 }, "tail": { "text": "amprenavir", "start": 20, "end": 30 } } ] } }

[]

Within 24 hours of fluid restriction and cessation of desmopressin , her symptoms and hyponatremia resolved .

{ "relations": { "adverse effect": [ { "head": { "text": "hyponatremia", "start": 86, "end": 98 }, "tail": { "text": "desmopressin", "start": 54, "end": 66 } } ] } }

[]

A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma .

{ "relations": { "adverse effect": [ { "head": { "text": "ulcer", "start": 128, "end": 133 }, "tail": { "text": "theophylline", "start": 42, "end": 54 } }, { "head": { "text": "ulcer", ...

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High - dose intravenous mannitol infusion in various clinical settings may result in acute renal failure ( ARF ) .

{ "relations": { "adverse effect": [ { "head": { "text": "acute renal failure", "start": 85, "end": 104 }, "tail": { "text": "mannitol", "start": 24, "end": 32 } }, { "head": { "text": "...

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This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving ' standard ' doses of dexamethasone as part of the antiemetic regimen used in cisplatin - based combination chemotherapy .

{ "relations": { "adverse effect": [ { "head": { "text": "bilateral avascular necrosis of the femoral heads", "start": 30, "end": 79 }, "tail": { "text": "dexamethasone", "start": 125, "end": 138 } } ] } ...

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CASE SUMMARY : A 46-year - old African - American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B , then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time .

{ "relations": { "adverse effect": [ { "head": { "text": "grand mal seizures", "start": 76, "end": 94 }, "tail": { "text": "amphotericin B", "start": 126, "end": 140 } } ] } }

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Because psoralens sensitize skin to ultraviolet A light , phototoxic reactions are the most frequent adverse effect of this treatment .

{ "relations": { "adverse effect": [ { "head": { "text": "phototoxic reactions", "start": 58, "end": 78 }, "tail": { "text": "psoralens", "start": 8, "end": 17 } } ] } }

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We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy .

{ "relations": { "adverse effect": [ { "head": { "text": "supravenous hyperpigmentation", "start": 32, "end": 61 }, "tail": { "text": "CHOP", "start": 78, "end": 82 } } ] } }

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The authors present a case study of a mentally healthy man who repeatedly experienced short - lived , obsessional - like suicidal ideas and images after ingestion of the anti - fungal drug ketoconazole .

{ "relations": { "adverse effect": [ { "head": { "text": "obsessional - like suicidal ideas and images", "start": 102, "end": 146 }, "tail": { "text": "ketoconazole", "start": 189, "end": 201 } } ] } }

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After extensive neurological ' work up ' , we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid .

{ "relations": { "adverse effect": [ { "head": { "text": "anisocoria", "start": 64, "end": 74 }, "tail": { "text": "scopolamine", "start": 106, "end": 117 } } ] } }

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We assume that rIFN - gamma induced the de novo development of SLE in our patient .

{ "relations": { "adverse effect": [ { "head": { "text": "SLE", "start": 63, "end": 66 }, "tail": { "text": "rIFN - gamma", "start": 15, "end": 27 } } ] } }

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Atrial fibrillation following methylprednisolone pulse therapy .

{ "relations": { "adverse effect": [ { "head": { "text": "Atrial fibrillation", "start": 0, "end": 19 }, "tail": { "text": "methylprednisolone", "start": 30, "end": 48 } } ] } }

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One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin .

{ "relations": { "adverse effect": [ { "head": { "text": "erythema multiforme", "start": 56, "end": 75 }, "tail": { "text": "griseofulvin", "start": 89, "end": 101 } } ] } }

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She was receiving phenytoin sodium 300 mg / day ; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia .

{ "relations": { "adverse effect": [ { "head": { "text": "leukopenia", "start": 148, "end": 158 }, "tail": { "text": "carbamazepine", "start": 50, "end": 63 } }, { "head": { "text": "leu...

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We describe the case of acute hepatitis induced by gliclazide , a second generation sulfonylurea .

{ "relations": { "adverse effect": [ { "head": { "text": "acute hepatitis", "start": 24, "end": 39 }, "tail": { "text": "gliclazide", "start": 51, "end": 61 } } ] } }

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OBJECTIVE : To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine .

{ "relations": { "adverse effect": [ { "head": { "text": "allergic reactions", "start": 91, "end": 109 }, "tail": { "text": "capecitabine", "start": 113, "end": 125 } } ] } }

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A patient with chronic myeloid leukaemia treated with busulphan for 4 - 5 years , developed signs of busulphan toxicity and portal hypertension with ascites , oesophageal varices and jaundice .

{ "relations": { "adverse effect": [ { "head": { "text": "ascites", "start": 149, "end": 156 }, "tail": { "text": "busulphan", "start": 54, "end": 63 } }, { "head": { "text": "jaundice",...

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Niflumic acid - induced skeletal fluorosis : iatrogenic disease or therapeutic perspective for osteoporosis ?

{ "relations": { "adverse effect": [ { "head": { "text": "skeletal fluorosis", "start": 24, "end": 42 }, "tail": { "text": "Niflumic acid", "start": 0, "end": 13 } } ] } }

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Hyponatraemia developed after rechallenge with controlled release carbamazepine .

{ "relations": { "adverse effect": [ { "head": { "text": "Hyponatraemia", "start": 0, "end": 13 }, "tail": { "text": "carbamazepine", "start": 66, "end": 79 } } ] } }

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There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea .

{ "relations": { "adverse effect": [ { "head": { "text": "CML", "start": 71, "end": 74 }, "tail": { "text": "hydroxyurea", "start": 97, "end": 108 } } ] } }

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The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril - induced acute renal failure .

{ "relations": { "adverse effect": [ { "head": { "text": "acute renal failure", "start": 142, "end": 161 }, "tail": { "text": "captopril", "start": 122, "end": 131 } } ] } }

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Since 1979 , over 30 published case reports have documented the relationship between phenylpropanolamine and stroke .

{ "relations": { "adverse effect": [ { "head": { "text": "stroke", "start": 109, "end": 115 }, "tail": { "text": "phenylpropanolamine", "start": 85, "end": 104 } } ] } }

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DISCUSSION : To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept .

{ "relations": { "adverse effect": [ { "head": { "text": "tuberculous uveitis", "start": 65, "end": 84 }, "tail": { "text": "etanercept", "start": 110, "end": 120 } } ] } }

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We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome , a rare congenital disorder .

{ "relations": { "adverse effect": [ { "head": { "text": "interstitial hypoxaemiant pneumonitis", "start": 22, "end": 59 }, "tail": { "text": "flecainide", "start": 80, "end": 90 } } ] } }

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Methotrexate - induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis : report of five cases and review of the literature .

{ "relations": { "adverse effect": [ { "head": { "text": "pneumonitis", "start": 23, "end": 34 }, "tail": { "text": "Methotrexate", "start": 0, "end": 12 } } ] } }

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While 40 mg / day of prednisolone improved hepatic dysfunction dramatically , her diabetic milieu deteriorated seriously .

{ "relations": { "adverse effect": [ { "head": { "text": "diabetic milieu deteriorated", "start": 82, "end": 110 }, "tail": { "text": "prednisolone", "start": 21, "end": 33 } } ] } }

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Ulcerating enteritis associated with flucytosine therapy .

{ "relations": { "adverse effect": [ { "head": { "text": "Ulcerating enteritis", "start": 0, "end": 20 }, "tail": { "text": "flucytosine", "start": 37, "end": 48 } } ] } }

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CONCLUSION : This rare case of PTU - induced ANCA - associated vasculitis manifested with ototoxicity in combination with systemic involvement .

{ "relations": { "adverse effect": [ { "head": { "text": "ANCA - associated vasculitis", "start": 45, "end": 73 }, "tail": { "text": "PTU", "start": 31, "end": 34 } }, { "head": { "text"...

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We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding .

{ "relations": { "adverse effect": [ { "head": { "text": "HUS", "start": 36, "end": 39 }, "tail": { "text": "MMC", "start": 46, "end": 49 } }, { "head": { "text": "massive pulmonary blee...

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CONCLUSION : These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers .

{ "relations": { "adverse effect": [ { "head": { "text": "corneal ulcers", "start": 85, "end": 99 }, "tail": { "text": "moxifloxacin", "start": 38, "end": 50 } } ] } }

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CONCLUSION : During and after IFN therapy , OCT is a useful examination technique for revealing macular edema in patients who have decreased vision .

{ "relations": { "adverse effect": [ { "head": { "text": "decreased vision", "start": 131, "end": 147 }, "tail": { "text": "IFN", "start": 30, "end": 33 } }, { "head": { "text": "macular...

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Although the two local anesthetics usually do not cause methemoglobinemia , we suspect that the displacement of lidocaine from protein binding by bupivacaine , in combination with metabolic acidosis and treatment with other oxidants , was the reason for the development of methemoglobinemia .

{ "relations": { "adverse effect": [ { "head": { "text": "methemoglobinemia", "start": 56, "end": 73 }, "tail": { "text": "lidocaine", "start": 112, "end": 121 } } ] } }

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Here we describe another case of VOD occurring after LT , but in which the causative role was played by azathioprine .

{ "relations": { "adverse effect": [ { "head": { "text": "VOD", "start": 33, "end": 36 }, "tail": { "text": "azathioprine", "start": 104, "end": 116 } } ] } }

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Hypo - oestrogenic and anabolic / androgenic side - effects of danazol are well known by the gynaecologist and some of them are present in > 50 % of patients being treated for endometriosis .

{ "relations": { "adverse effect": [ { "head": { "text": "Hypo - oestrogenic and anabolic / androgenic side - effects", "start": 0, "end": 59 }, "tail": { "text": "danazol", "start": 63, "end": 70 } } ] }...

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The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine .

{ "relations": { "adverse effect": [ { "head": { "text": "transient intraoperative hypertension", "start": 28, "end": 65 }, "tail": { "text": "epinephrine", "start": 133, "end": 144 } } ] } }

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Inadvertent and accidental epinephrine overdose might result in potentially lethal complications .

{ "relations": { "adverse effect": [ { "head": { "text": "lethal complications", "start": 76, "end": 96 }, "tail": { "text": "epinephrine", "start": 27, "end": 38 } } ] } }

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Acute pancreatitis is a known , although rare , complication of mesalamine treatment .

{ "relations": { "adverse effect": [ { "head": { "text": "Acute pancreatitis", "start": 0, "end": 18 }, "tail": { "text": "mesalamine", "start": 64, "end": 74 } } ] } }

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From these data , acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d - penicillamine therapy .

{ "relations": { "adverse effect": [ { "head": { "text": "acute generalized dystonia", "start": 18, "end": 44 }, "tail": { "text": "d - penicillamine", "start": 123, "end": 140 } }, { "head": { ...

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